Figure 6
Post-meningitic (PM) mice deficient in TLR2/4 signalling displayed ameliorated nocturnal hyperactivity throughout the adaptation phases in the long-term. All data are from the re-testing protocol (R2). The frequency of nocturnal corner visits (A) in each two-day free adaptation (FA), nosepoke adaptation (NA) and drinking session adaptation (DSA) was summed. Since TLR2/4 deficiency affects exploratory behaviour in uninfected mice30, the corresponding delta value of corner visit frequency (A) are presented to show genotype difference related to pneumococcal meningitis. Similarly, delta frequencies of visits with nosepokes (B) and licks (C) are plotted over each adaptations phase. Total n as shown in Fig. 3. #p < 0.05, overall genotype effect as analysed by mixed ANOVA by GLM repeated measures. *p < 0.05, genotype effect as analysed by Fisher’s LSD. WT = wild-type; GKO = gene knockout.
