Table 2 Liver microsomal stability of cordycepin tested with rat and human liver microsomes (mean ± SD, n = 3).
Rat liver microsome | Human liver microsome | |||||||
|---|---|---|---|---|---|---|---|---|
NADPH | + | + | − | − | + | + | − | − |
Pentostatin | + | − | + | − | + | − | + | − |
CLint (mL/min/kg) | ND | 392.2 ± 31.3 | ND | 390.0 ± 51.4 | ND | 181.4 ± 13.9 | ND | 179.1 ± 5.3 |
Fh (%), well-stirred modela | ND | 12.4 ± 0.9 | ND | 12.5 ± 1.5 | ND | 10.3 ± 0.7 | ND | 10.4 ± 0.3 |
Fh (%), parallel-tube modela | ND | 0.1 ± 0.0 | ND | 0.1 ± 0.1 | ND | 0.0 ± 0.0 | ND | 0.0 ± 0.0 |
