Figure 4
From: β-catenin regulates the formation of multiple nephron segments in the mouse kidney
β-catenin is required for the formation of differentiated proximal tubule cells with strong LTL staining. Hnf4a marks both presumptive and differentiated proximal tubules. In the control kidney, presumptive proximal tubules show strong Cdh6 signal and weak LTL staining while differentiated proximal tubules show weak Cdh6 signal and strong LTL staining. In the β-catenin loss-of-function mutant kidney by Osr2Cre, all Hnf4a+ cells show strong Cdh6 signal, failing to form differentiated proximal tubules with strong LTL staining. Images are representative of three independent experiments. Stage E18.5. Scale bar: 100 μm.
