Figure 6
From: β-catenin regulates the formation of multiple nephron segments in the mouse kidney
Expression of a stable form of β-catenin inhibits proper nephron patterning. The β-catenin gain-of-function mutant kidney by Wnt4GFPcre fails to form properly patterned nephrons. (A) No proximal tubules or Slc12a1+ loops of Henle are formed in the mutant kidney. (B) No glomeruli or Slc12a3+ distal tubules are formed in the mutant kidney. Images are representative of three independent experiments. Stage E18.5. Scale bar: 100 μm.
