Figure 1

Characterization of diabetic phenotype and body weight during the liraglutide treatment period. For intraperitoneal glucose tolerance tests (IPGTTs), blood glucose levels were measured after administration of glucose (2 g/kg i.p.), and the area under the curve was calculated: (a,b) IPGTT at the beginning of the experiment, (c,d) IPGTT after 4 months of chronic liraglutide treatment. For ethical reasons, IPGTT was not performed on animals who had already developed hyperglycemia. (e,f) Basal blood glucose levels at different ages. (g) Body weight change over 6 months of liraglutide chronic treatment. The data were compared using factorial ANOVA followed by Fisher’s LSD tests; ***p < 0.001. The data are presented as the mean ± SEM, n = 4–16 per group.