Figure 8 | Scientific Reports

Figure 8

From: Atomistic simulations shed new light on the activation mechanisms of RORγ and classify it as Type III nuclear hormone receptor regarding ligand-binding paths

Figure 8

Structural alignment of the nuclear hormone receptor family from the following x-ray structure PDB IDs: RORγ (5vb7); PPARγ (1prg); AR (2q7j); ERα (1qkt); GR (4p6x); MR (2aa2) and PR (1a28). Coloring for RORγ and PPARγ are in blue and red, respectively while the others are in green. The agonist molecule and the H479-Y502 “agonist lock” in RORγ are shown with sphere and stick representation, respectively. The area depicted in dash-circle illustrates a “backdoor” entry in RORγ and PPARγ while it is totally covered with a long loop across the entrance in other NHRs proteins.

Back to article page