Table 1 Physiological parameters of mice at 24 weeks of age.

From: Tubular Deficiency of Heterogeneous Nuclear Ribonucleoprotein F Elevates Systolic Blood Pressure and Induces Glycosuria in Mice

 

Male

Female

Ctrl

Hnrnpf KO

p

Ctrl

Hnrnpf KO

p

Body weight (g)

34.35 ± 0.96

34.94 ± 0.68

NS

24.81 ± 0.89

23.55 ± 0.86

NS

KW/BW (mg/g)

9.35 ± 0.58

8.38 ± 0.41

NS

9.97 ± 0.29

9.05 ± 0.45

NS

GFR(µL/min)/BW(g)

7.5 ± 0.45

7.7 ± 0.57

NS

7.9 ± 0.64

6.8 ± 0.34

NS

Glomerular tuft volume (103 µm3)

117.3 ± 8.92

128.2 ± 10.94

NS

120.2 ± 9.90

129.5 ± 5.88

NS

Urine volume (µl/24 h)

871.7 ± 36.1

1198.0 ± 102.7

*

265.0 ± 63.3

505.8 ± 41.5

**

Food intake (mg/24 h)

333.3 ± 42.2

333.3 ± 33.3

NS

566.7 ± 76.0

516.7 ± 54.3

NS

Water intake (ml/24 h)

1.97 ± 0.08

2.37 ± 0.24

NS

2.30 ± 0.29

2.55 ± 0.13

NS

Serum Na (mmol/L)

149.7 ± 2.3

151.5 ± 1.4

NS

147.6 ± 2.1 #

148.7 ± 1.4

NS

Serum Ca (mmol/L)

2.22 ± 0.03

2.21 ± 0.04

NS

2.34 ± 0.11 #

2.20 ± 0.03

NS

Serum P (mmol/L)

2.89 ± 0.20

2.95 ± 0.29

NS

3.37 ± 0.36

3.13 ± 0.14

NS

Urine Na/Cr (mmol/g Cr)

741.0 ± 73.1

709.8 ± 25.0

NS

398.5 ± 61.1

353.2 ± 32.9

NS

Urine P/Cr (mmol/g Cr)

107.2 ± 17.2

101.2 ± 17.9

NS

73.3 ± 10.9

79.7 ± 12.6

NS

  1. Values are mean ± SEM; n = 6/group.
  2. KW/BW. Kidney Weight/Body Weight; Na. sodium; Ca. calcium; P. phosphorus; Cr. creatinine.
  3. **p < 0.01, *p < 0.05, NS, not significant.
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