Figure 5 | Scientific Reports

Figure 5

From: Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Figure 5

Gene Ontology (GO) enrichment analysis of the sarkosyl-insoluble proteome. (A) Enriched cellular components; (B) Enriched molecular functions; (C) Top 10 enriched pathways based on protein upregulation in 24-month-old TG vs. WT mice, according to the Kyoto Encyclopaedia of Genes and Genomes (KEGG); (D) Top 10 enriched KEGG pathways based on protein downregulation in 24-month-old TG vs. WT mice. Functional annotation clustering was generated by using DAVID software. Maximum enrichment probability (P value) was based on an EASE score threshold value of 0.05.

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