Table 1 Autoradiography of [18F]Flortaucipir binding sites in APPswe/PS1ΔE9 mice.

From: Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease

Brain region

3 months

6 months

12 months

18 months

24 months

Correlation with Gallyas-positive fraction

Cortical

WT

APP/PS1

WT

APP/PS1

WT

APP/PS1

WT

APP/PS1

WT

APP/PS1

Pearson r (Significance)

Frontal

2.2 ± 0.7

3.6 ± 1.3

2.3 ± 0.9

10.0 ± 1.6

4.0 ± 1.0

46.7 ± 2.7***

4.7 ± 1.1

53.2 ± 3.0

4.2 ± 1.0

55.2 ± 5.7

0.74 (P < 0.001)

Motor

2.5 ± 0.5

2.8 ± 0.8

2.5 ± 0.7

7.3 ± 1.3

3.2 ± 0.7

31.0 ± 1.3***

3.2 ± 0.8

45.1 ± 2.0

4.3 ± 1.1

55.7 ± 2.9

0.90 (P < 0.001)

Somatosensory

5.2 ± 1.3

5.0 ± 2.0

4.0 ± 0.9

11.6 ± 1.9

6.7 ± 4.5

34.9 ± 2.6***

6.5 ± 1.8

50.3 ± 1.5

5.8 ± 1.6

57.8 ± 2.7

0.93 (P < 0.001)

Visual

6.8 ± 2.4

4.7 ± 1.4

2.4 ± 1.1

11.8 ± 2.5

8.2 ± 1.8

35.5 ± 3.2***

6.3 ± 1.9

52.9 ± 2.8

5.0 ± 1.3

56.4 ± 2.9

0.92 (P < 0.001)

Entorhinal

3.2 ± 1.0

2.9 ± 1.0

3.3 ± 0.8

8.8 ± 1.1

6.7 ± 1.5

29.8 ± 1.9***

4.1 ± 2.6

40.6 ± 3.8

6.3 ± 1.7

42.8 ± 4.0

0.84 (P < 0.001)

Subcortical

Hippocampus

3.1 ± 1.3

2.8 ± 0.8

3.0 ± 0.7

7.5 ± 1.3

4.3 ± 1.3

31.3 ± 2.4***

4.3 ± 1.2

40.9 ± 2.5

5.6 ± 1.5

49.1 ± 3.1

0.86 (P < 0.001)

Striatum

2.6 ± 1.4

3.1 ± 1.0

3.1 ± 0.7

4.8 ± 0.9

4.4 ± 1.1

10.9 ± 2.4

5.1 ± 1.5

17.2 ± 1.2

5.4 ± 1.5

19.7 ± 2.8**

0.64 (P < 0.001)

Amygdala

1.8 ± 1.5

2.9 ± 0.9

3.1 ± 0.7

7.4 ± 1.0

4.2 ± 1.1

27.8 ± 2.9***

5.2 ± 1.5

40.0 ± 2.5

5.2 ± 1.1

47.7 ± 4.8

0.79 (P < 0.001)

Thalamus

2.6 ± 0.6

2.2 ± 0.6

3.3 ± 1.0

3.5 ± 0.5

3.6 ± 0.9

11.2 ± 3.2

3.9 ± 1.3

17.5 ± 2.0***

4.1 ± 1.0

27.2 ± 4.5

0.87 (P < 0.001)

Cerebellum

4.2 ± 0.8

3.1 ± 1.1

4.1 ± 1.2

10.3 ± 1.1

3.3 ± 1.0

23.0 ± 3.1***

4.5 ± 1.5

31.2 ± 3.6

5.8 ± 1.6

32.4 ± 3.7

0.83 (P < 0.001)

Mean binding levels (all brain regions)

3.4 ± 1.1

3.3 ± 1.1

3.1 ± 0.9

8.3 ± 1.3

4.9 ± 1.5

28.2 ± 2.6

4.8 ± 1.5

38.9 ± 2.5

5.2 ± 1.3

44.4 ± 3.7

0.92 (P < 0.001)

  1. Fresh-frozen brain sections from APPswe/PS1ΔE9 and age-matched wild-type (WT) animals were incubated with 38.4 ± 9.6 MBq [18F]Flortaucipir for a period of 60 min (specific activity: 145 ± 68 GBq/µmol). Autoradiography data are presented as the mean specific binding of [18F]Flortaucipir (kBq/mL) ± standard error of the mean in brain regions of 5–6 animals/group. By 24 months of age, [18F]Flortaucipir binding in APPswe/PS1ΔE9 mice had increased across all brain areas examined compared to age-matched WT animals. The age-dependent increase in [18F]Flortaucipir binding levels was positively correlated with the progressive increase in Gallyas-positive argyrophilic signal, in all TG brain areas examined. **P < 0.01, ***P < 0.001 vs. age-matched littermate control mice, Bonferroni post-hoc tests. Symbols of significant differences between groups of 24 & 18 vs. 3, 6 and 12-month-old-mice were omitted from the table for clarity of presentation.
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