Table 2 Proteomics of sarkosyl-insoluble tau.
UniProt | Protein (Sequence) | Involvement | TG vs. WT | TG vs. WT | TG | WT | AD vs. non-AD | ||
|---|---|---|---|---|---|---|---|---|---|
Accession Number | 3 M | 24 M | 24 vs. 3 M | 24 vs. 3 M | |||||
B1AQW2 | Microtubule-associated protein | Tau | 0.86 | 1.00 | 2.06 | 1.77 | 37.15 | ||
(KVAVVRTPPKSPSASKS) | pT231 | 0.87 | 26.55 | 23.81 | 0.78 | 0.94 | |||
(KSPVVSGDTSPRH) | pS396, pS400, pS404 | 1.46 | 2.02 | 1.00 | 0.67 | 1.16 | |||
P10637-3 | Microtubule-associated protein tau | Tau Isoform-B | 0.61 | 3.21 | 4.52 | 0.86 | Fetal form present | ||
Multiple | Small nuclear ribonucleoproteins (SnRPN) | Core spliceosomal components | Age- and genotype-specific regulation (Supplementary Dataset) | ||||||
Multiple | Heterogeneous nuclear ribonucleoproteins | Exon 10 splicing regulation | Multiple proteins regulated (Supplementary Dataset) | ||||||
Q8BL97 | Serine/arginine-rich splicing factor 7 | Exon 10 exclusion | 0.82 | 1.05 | 1.11 | 0.87 | 0.69 | ||
Q9Z0H4 | CUGBP Elav-like family member 2 | Exon 10 exclusion | 0.40 | 1.85 | 1.94 | 0.42 | 1.49 | ||
P62996 | Transformer-2 protein homolog beta | Exon 10 inclusion | 0.85 | 1.13 | 0.74 | 0.56 | Not identified | ||
Multiple | Tubulin | Tau binding partner | Alpha & beta chains regulated (Supplementary Dataset) | ||||||
P60710 | Actin, cytoplasmic 1 | Tau binding partner | 0.80 | 0.53 | 1.43 | 2.16 | 0.71 | ||
P08551, P08553, P19246 | Neurofilament | Tau binding partner | Light, medium & heavy polypeptides regulated (Supplementary Dataset) | ||||||
Multiple | Ribosomal proteins 60 S, 40 S | Tau binding partner | Age- and genotype-specific changes, particularly in the acidic proteins of the 60 S subunit (Supplementary Dataset) | ||||||
O08788 | Dynactin | Tau binding partner | 1.01 | 1.34 | 0.79 | 0.59 | Not identified | ||
P28738 | Kinesin | Tau binding partner | 0.92 | 0.75 | 1.03 | 1.28 | 0.90 | ||
P11499, Q80Y52, Q3UAD6 | Heat shock protein 90 | Tau binding partner | Isoforms alpha & beta identified (Supplementary Dataset) | ||||||
P48722, P17156, Q3U2G2, Q8K0U4 | Heat shock protein 70 | Tau binding partner | Members 2 & 4 common in mice & humans (Supplementary Dataset) | ||||||
P0DP26 | Calmodulin-1 | Tau binding partner | 1.68 | 0.31 | 0.68 | 3.63 | 0.93 | ||
Q3UY00 | S100β | Tau binding partner | 0.99 | 0.52 | 1.27 | 2.44 | 0.34 | ||
O55042 | α-Synuclein | Tau binding partner | 0.81 | 0.70 | 1.29 | 1.49 | 0.79 | ||
A8IP69, P68510, F6VW30, Q9CQV8, P63101 | 14-3-3 proteins | Tau binding partner | Isoform-specific changes (Supplementary Dataset) | ||||||
Q3TXU4 | Apopoliprotein E | Tau binding partner/AD risk factor | 0.65 | 3.58 | 7.51 | 1.37 | Not identified | ||
O08539 | Bin 1 | Tau binding partner/AD risk factor | 2.11 | 0.44 | 0.71 | 3.41 | 1.44 | ||
Q549A5 | Clusterin | Tau interacting partner AD risk factor | 1.17 | 1.82 | 1.87 | 1.20 | Not identified | ||
P11798, Q923T9, A0A0G2JGS4 | Ca2+/calmodulin-dependent protein kinase II | Tau kinase | Multiple subunits identified (Supplementary Dataset) | ||||||
P63318 | Protein kinase C, gamma type | Tau kinase | 0.71 | 1.48 | 1.30 | 0.62 | 1.05 | ||
P31324 | Cyclic-AMP dependent protein kinase II | Tau kinase | 0.57 | 0.91 | 1.61 | 1.01 | 0.84 | ||
Q63810 | Calcineurin subunit B type I | Tau phosphatase | 1.36 | 0.34 | 0.96 | 3.84 | Not identified | ||
Q76MZ3 | Serine/threonine-protein phosphatase 2A | Tau phosphatase | 1.25 | 0.58 | 0.87 | 1.88 | 0.73 | ||
