Figure 2 | Scientific Reports

Figure 2

From: Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis

Figure 2

Enriched motifs with H3K4me3 and H3K27me3 marks in T cells. CD4+ T cells from spleens of naïve, MOG + vehicle and MOG + CBD treated mice were isolated as described in the Fig. 1 legend. Enrichment of motifs was identifed by HOMER sofwar using ChIP-seq data. Top 10 known transcription binding motifs are presented here. (a) Enriched motifs with H3K4me3 mark in MOG + vehich sample compared to Naïve sample; (b) Enriched motifs with H3K4me3 mark in MOG-sensitized T cells EAE mice treated with CBD compared to vehicle treatment; (c) Enriched motifs with H3K27me3 mark in MOG-sensitized T cells from EAE mice compared to Naïve; (d) Enriched motifs with H3K27me3 mark in MOG-sensitized T cells from EAE mice treated with CBD compared to vehicle treatment.

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