Figure 3 | Scientific Reports

Figure 3

From: A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle

Figure 3

Selection of differentially regulated shared genes and percentage of genes regulated in different fashions and their related pathways. (A) Venn diagram showing the number of differentially regulated genes in cancer cells with different treatments. (B) Percentage of genes that were regulated in ‘synergistic’ (yellow) and ‘antagonistic’ (blue) fashion in A431 (doxorubicin) and MDA-MB-231 (5-Fu) cells. (C) Percentage of synergistically regulated genes in different KEGG pathways. (D) Percentage of up-regulated and down-regulated genes for single chemotherapy drug treatment in different KEGG pathways.

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