Figure 2

The frequency and distribution of somatic POLE and POLD1 variants in Chinese cancer patients, and a comparison with COSMIC database. All variants for POLE and POLD1 in this study are shown in panel A and panel B, respectively, including 50 POLE variants (from 56 subjects, including 6 repeated sites) and 35 POLD1 variants. The frequency and distribution of the top 40 variants of POLE and POLD1 from COSMIC database are shown for comparison in panel C and panel D, respectively. The types of variants are indicated by different colors.