Table 2 RNA-Seq results from modA15 and modA18 ON/OFF pairs. Only genes with >2 fold expression differences are shown.

From: Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions

Locus tag

Protein product

Fold change (ON:OFF)

log2 fold change (ON:OFF)

logCPM

PValue

FDR

UP in modA15 ON

DLJ98_09775

ResA15

7.13

2.83

9.06

2.48E-12

1.22E-09

DLJ98_09780

ModA15

3.18

1.67

8.47

4.77E-11

6.73E-09

DLJ98_05145

DNA binding transcriptional regulator Fis

2.35

1.23

7.34

2.54E-08

5.33E-07

DLJ98_08705

DNA polymerase 1

2.05

1.04

6.98

1.35E-08

3.55E-07

DOWN in modA15 ON

DLJ98_05515

D-ribose pyranase

0.11

−3.24

5.71

3.90E-10

3.59E-08

DLJ98_05530

ribose ABC transporter substrate-binding protein RbsB

0.12

−3.11

8.52

3.18E-13

4.94E-10

DLJ98_07630

ornithine carbamoyltransferase

0.18

−2.46

10.64

3.15E-12

1.22E-09

DLJ98_07625

ArcC carbamate kinase

0.22

−2.21

10.59

8.78E-12

2.27E-09

DLJ98_04590

TbpA extracellular solute binding protein

0.22

−2.16

8.18

1.20E-11

2.66E-09

DLJ98_00210

DUF465 domain-containing protein

0.23

−2.12

7.92

2.76E-09

1.26E-07

DLJ98_03210

sodium/proline symporter PutP

0.23

−2.11

9.56

4.72E-11

6.73E-09

DLJ98_04585

ABC transporter substrate binding protein

0.24

−2.05

8.66

4.15E-12

1.29E-09

DLJ98_05485

acid phosphatase AphA

0.29

−1.81

11.77

6.72E-10

4.54E-08

DLJ98_09395

dithiol-disulfide isomerase

0.29

−1.79

5.08

2.66E-07

2.74E-06

DLJ98_06725

ketol-acid reductoisomerase

0.30

−1.74

10.70

3.10E-12

1.22E-09

DLJ98_04420

YjhT family mutarotase

0.31

−1.68

9.06

2.11E-11

4.10E-09

DLJ98_04410

sialic acid-binding protein

0.36

−1.48

11.85

4.16E-10

3.59E-08

DLJ98_02355

cold shock domain protein CspD

0.37

−1.44

9.38

3.45E-09

1.37E-07

DLJ98_01875

class II fumarate hydratase

0.37

−1.43

8.89

4.45E-11

6.73E-09

DLJ98_00385

NADP-dependent malic enzyme

0.37

−1.42

11.15

4.09E-10

3.59E-08

DLJ98_08875

universal stress protein UspA

0.39

−1.37

10.15

9.74E-09

2.75E-07

DLJ98_08840

galactose ABC transporter substrate-binding protein

0.39

−1.36

12.37

7.16E-10

4.63E-08

DLJ98_07615

Lrp/AsnC family transcriptional regulator

0.40

−1.33

5.47

2.66E-06

1.77E-05

DLJ98_03795

malate dehydrogenase

0.40

−1.32

8.84

6.57E-10

4.54E-08

DLJ98_06225

serine transporter

0.43

−1.23

4.41

4.35E-07

4.12E-06

DLJ98_06035

ribosome-associated translation inhibitor RaiA

0.44

−1.19

8.38

2.83E-08

5.77E-07

DLJ98_04600

ferric ABC transporter ATP-binding protein

0.45

−1.17

7.52

3.03E-10

3.29E-08

DLJ98_04425

isoprenylcysteine carboxylmethyltransferase family protein

0.45

−1.16

3.41

1.95E-05

8.71E-05

DLJ98_06760

glycerophosphodiester phosphodiesterase

0.45

−1.15

11.97

9.32E-11

1.21E-08

DLJ98_05535

ribokinase

0.45

−1.14

6.89

1.26E-08

3.44E-07

DLJ98_00010

autonomous glycyl radical cofactor GrcA

0.45

−1.14

10.22

4.87E-07

4.45E-06

DLJ98_09550

transporter

0.45

−1.14

9.10

6.39E-08

1.03E-06

DLJ98_07785

phospho-sugar mutase

0.46

−1.12

11.42

3.18E-10

3.29E-08

DLJ98_10115

phosphonate ABC transporter substrate-binding protein

0.46

−1.11

9.63

5.19E-09

1.75E-07

DLJ98_03455

uracil phosphoribosyltransferase

0.47

−1.10

9.58

1.55E-09

8.04E-08

DLJ98_05540

LacI family DNA-binding transcriptional regulator

0.48

−1.07

6.34

2.98E-09

1.28E-07

DLJ98_04415

C4-dicarboxylate ABC transporter permease

0.48

−1.07

10.06

3.31E-09

1.35E-07

DLJ98_04335

pyridoxal phosphate-dependent aminotransferase

0.48

−1.07

1.74

0.000137

0.000429

DLJ98_10260

TRAP transporter substrate-binding protein

0.48

−1.07

5.31

6.47E-08

1.04E-06

DLJ98_04915

NAD nucleotidase

0.48

−1.05

11.61

3.03E-10

3.29E-08

DLJ98_03460

uracil permease

0.49

−1.03

7.40

5.75E-10

4.25E-08

DLJ98_01765

hypothetical

0.50

−1.01

5.75

0.002699

0.005533

DLJ98_09605

polymerase

0.50

−1.01

9.38

5.30E-09

1.75E-07

DLJ98_04115

hypoxanthine phosphoribosyltransferase

0.50

−1.00

5.82

1.19E-07

1.61E-06

UP in modA18 ON

DLK00_02840

ResA18

7.92

2.99

9.49

1.83E-11

2.98E-08

DLK00_02880

DmsB

4.34

2.12

5.54

3.03E-08

2.47E-05

DLK00_02885

DmsC

3.54

1.83

5.67

1.77E-06

0.00032

DLK00_02890

DmsD

2.90

1.54

3.96

1.65E-05

0.000958

DLK00_09770

flippase

2.51

1.33

10.48

0.173477

0.33405

DLK00_05505

hypothetical

2.13

1.09

4.85

3.55E-06

0.000414

DLK00_05510

hypothetical

2.07

1.05

4.66

2.15E-05

0.001002

DLK00_05500

regulatory protein GemA

2.00

0.98

5.23

5.94E-06

0.00051

DOWN in modA18 ON

DLK00_10225

DUF935 domain-containing protein

0.50

−0.95

0.17

0.008281

0.045171

DLK00_07345

Lic3A/Lic3B

0.31

−1.70

5.77

2.47E-06

0.000352