Figure 6 | Scientific Reports

Figure 6

From: Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells

Figure 6

In vivo inflammatory and host responses. (a) Representative histograms of flow cytometry analysis showing HLA-DR expression on hBMSC pre-implantation; monoclonal antibody control (yellow) and the stained cells (red). (b) Mouse relative mRNA expressions 1 week post-implanting of the BCP and cell constructs in vivo. Y axes represent mRNA expressions for IL-1α, IL-1β, IL-6 (p < 0.05). (c) Histological micrographs after 1 week of the different groups implanted. Magnification 400× showing the different inflammatory cells recruited. L - lymphocytes, N - neutrophils, P - plasma cells. (d) Histological micrographs after 11 weeks showing recruited foreign body giant cells (black arrows) and a cellular connective tissue with scattered fibroblast-like cells in Direct(PL) (red arrows). Scale 100 µm.

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