Figure 1 | Scientific Reports

Figure 1

From: Electrochemotherapy induces tumor regression and decreases the proliferative index in canine cutaneous squamous cell carcinoma

Figure 1The alternative text for this image may have been generated using AI.

Evaluation of tumor volume, clinical response by tumor volume, mitotic index, intratumoral necrosis and Ki67 expression before and after treatment with ECT in dogs with cSCC. (A) The tumor volume before the treatment ranged from 0.14 to 112.9 cm³ (median of 4.64) and significantly decreased after treatment (p = 0.04), ranging from 0.11 to 118.2 cm³ (median of 1.49). (B) Evaluation of tumor size at D0 as a prognostic factor based on a cutoff of 5 cm. The volume at D0 had no impact on survival and no prognostic value (P > 0.05), and the response promoted by ECT was not significant (p = 0.332). (C) A decreased mitotic index at D21 (median of 1.5, ranging from 0 to 20) (P = 0.019) was observed. (D) More intratumoral necrosis was observed in tumor samples at D21 than at D0 (P = 0.041). (E) A lower proliferative index (p = 0.031) was observed at D21 than at D0.

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