Figure 2 | Scientific Reports

Figure 2

From: The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits

Figure 2

Des-fluoro-anacetrapib treatment decreases endothelial VCAM-1 and ICAM-1 expression in grafted veins in NZW rabbits. Right external jugular vein autologous end-to-side transplantation bypass grafting of the right common carotid artery was carried out in NZW rabbits maintained on regular chow (control) or chow supplemented with 0.14% (wt/wt) des-fluoro-anacetrapib (dfAna) as described in the legend to Fig. 1. VCAM-1 (Panel A) and ICAM-1 immunostaining (Panel B) of representative grafted vein cross-sections is shown (bar = 100 µm). Quantification of endothelial expression of VCAM-1 and ICAM-1 is shown in Panels (C,D), respectively. Data are expressed as individual points with the cross symbol indicating the mean ± SEM, n = 8 for the control group, n = 9 for the dfAna group, #p < 0.05 vs Control.

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