Figure 3 | Scientific Reports

Figure 3

From: The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits

Figure 3

Des-fluoro-anacetrapib treatment protects against grafted vein endothelial dysfunction in NZW rabbits. Right external jugular vein autologous end-to-side transplantation bypass grafting of the right common carotid artery was carried out in NZW rabbits maintained on regular chow (control) or chow supplemented with 0.14% (wt/wt) des-fluoro-anacetrapib (dfAna) as described in the legend to Fig. 1. Panel (A): Endothelial-dependent relaxation of pre-contracted grafted vein rings in response to acetylcholine (ACh). Panel (B): Endothelial-independent relaxation of pre-contracted grafted vein rings in response to sodium nitroprusside (SNP). Data are expressed as mean ± SEM, n = 8 for the control group, n = 9 for the dfAna group, *p < 0.05.

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