Figure 4 | Scientific Reports

Figure 4

From: The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits

Figure 4

Des-fluoro-anacetrapib treatment reduces grafted vein smooth muscle cell proliferation in NZW rabbits. Right external jugular vein autologous end-to-side transplantation bypass grafting of the right common carotid artery was carried out in NZW rabbits maintained on regular chow (control) or chow supplemented with 0.14% (wt/wt) des-fluoro-anacetrapib (dfAna) as described in the legend to Fig. 1. Panel (A): immunostaining of PCNA+ cells in grafted vein cross-sections (bar = 50 µm). Panel (B): Quantification of cell proliferation expressed as the % PCNA+ cells relative to the total number of cells in the intima and media. Data are expressed as individual points with the cross symbol indicating the mean ± SEM, n = 8 for the control group, n = 9 for the dfAna group, #p < 0.05 vs Control.

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