Figure 1 | Scientific Reports

Figure 1

From: Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

Figure 1

The organization of the RH1-LZI tandem of JIP3/4. (a) Schematic representation of the full JIP3/4 proteins. Sequence limits of JIP3 are indicated at the beginning of the known domains. RH1 and RH2: RILP homology 1 and 2; LZI and LZII: Leucine Zipper I and II; CTD: C-Terminal Domain. JNK: c-Jun N-terminal Kinase. The binding partners of JIP3/4 are indicated in red. (b) Sequence alignment of the N-terminal part consisting of the RH1-LZI tandem of human JIP3 and JIP4 homologs (NP_055948.2 and NP_001123999.1 accession numbers, respectively). Secondary structures are indicated above the sequence alignment. The repeated pattern ‘abcdefg’ of the heptad repeats of the Leucine Zipper I (LZI) is indicated above the sequence alignment with the characteristic hydrophobic residues at position ‘a’ and ‘d’ indicated in red.

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