Figure 2
Stratification of PLC patients based on the FGC (A) FGC values among the TIGER-LC cohort (n = 152) are plotted in rank order (left). By applying cut-off (dotted line, FGC = 0.2), TIGER-LC cohort was separated into an FGC high (HFGC; n = 101) and FGC low (LFGC; n = 51) group. The relative proportion of HCC and iCCA among HFGC and LFGC are shown (right). HCC and iCCA patients are shown in blue and orange colors, respectively. (B) Kaplan-Meier (KM) survival analysis based on the HFGC and LFGC subtype show significant difference in overall survival time. The statistical P-value by the Cox-Mantel log-rank test was depicted. (C) HFGC shows higher tFA values compared to the LFGC. P-value based on Welch’s two-sample t-test was depicted. (D) Heatmap shows copy number value of individual sample of Thai HCC corresponding to the correlated segments regions, respectively. Samples are grouped by the HFGC and LFGC in columns and segment regions are represented in rows according to the chromosomal location. (E) The frequency of SCNA among HFGC and LFGC subtype of Thai HCC are plotted corresponding to the correlated segmented region, respectively. The sample frequencies with copy number gain and loss (log2 (copy number) >0.2 or log2 (copy number) < −0.2) are shown in red and blue, respectively. Chromosome boundaries and centromere positions are indicated by vertical solid and dashed lines, respectively. Horizontal dashed blue lines indicate frequency of 50%. Horizontal dotted black lines indicate frequency of 20%. (F) Comparison of allelic imbalance frequency between HFGC and LFGC. The proportion of allelic imbalance of HFGC and LFGC of Thai HCC and Thai iCCA are plotted.
