Figure 5
Tumor-infiltrating lymphocytes (TILs) are related to FGC. (A,B) The association between PCC and immune score derived from a tumor (left panel of each) or non-tumor (right panel of each) tissue of Thai HCC and Thai iCCA are shown, respectively. (C–E) Log2 ratios of the mean of 22 types of TILs in LFGC to HFGC of Thai HCC (C) and Thai iCCA (E) are shown, respectively. TILs enriched in the LFGC or HFGC group are assigned as favorable or adverse and plotted as either blue or pink bar, respectively. (D–F) The association between FGC and the immune score of adverse (left panel) or favorable TILs (right panel) among Thai HCC (D) and Thai iCCA (F), derived from Fig. 5C,E, are shown, respectively. (G,H) Concordance and difference of the associations of FGC with 22 types of TILs between Thai HCC and Thai iCCA (G) or Thai HCC and TCGA HCC (H) are shown, respectively. The x-axis and y-axis indicate the coefficient estimates from Pearson’s correlation between FGC and the relative proportion of TIL subpopulations in Thai HCC and Y-axis represents for coefficient estimates from Pearson’s correlation between FGC and the relative proportion of TIL subpopulations in Thai iCCA or TCGA HCC. Red and blue bars indicate adverse and favorable associations, predicted by the association with FGC, respectively. Pink or green circled areas indicate TILs commonly associated with FGC among Thai PLC and TCGA HCC.
