Figure 7
Average Ktrans values for (A) PLGA NPs and (B) Gd-DTPA in the focal injury and contralateral brain when injected I.V. at various times after injury. NPs showed a time-dependent difference in uptake and retention kinetics as compared to Gd-DTPA where uptake and retention were not significantly affected by injection time. *indicates a statistical difference (p < 0.01) as determined by one-way ANOVA followed by Tukey’s post-test. Inlays show scaled Ktrans values for each injection time on the contralateral side of the brain.
