Table 2 Nanoparticle pharmacokinetic properties.

From: Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI

Particle

Distribution Half-life (t1/2,dist)51

Kel,dist [min−1]

Elimination Half-life (t1/2,elim)51

Kel,elim [min−1]

Area under concentration-time curve (AUC)

Cj-1

4.74 ± 1.58

0.16 ± 0.055

29.69 ± 2.53

0.024 ± 0.002

152 ± 59 [min mg mL−1]

PLGA

3.12 ± 1.33

0.25 ± 0.068

44.02 ± 14.23

0.017 ± 0.005

329 ± 130 [min mg mL−1]

Pro-NP

3.64 ± 1.79

0.23 ± 0.11

27.74 ± 10.19

0.029 ± 0.012

6116 ± 3200 [min mg mL−1]

Gd-DTPA

4.01 ± 2.47

0.23 ± 0.11

15.70 ± 8.50

0.056 ± 0.023

6.6 ± 3.8 [min mM]

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