Figure 7 | Scientific Reports

Figure 7

From: Suppression of BCL6 function by HDAC inhibitor mediated acetylation and chromatin modification enhances BET inhibitor effects in B-cell lymphoma cells

Figure 7

Synergistic effects of romidepsin and JQ1 in Raji B-cell lymphoma cells. (a) Combination index plot showing synergistic effect (arrow) of romidepsin (5 nM) plus JQ1 (1 µM) on the proliferation of Raji cells. (b) Western blot showing cleaved PARP1 and BCL-xL and γH2AX protein levels in Raji cells treated with romidepsin and/or JQ1 for the indicated times. Actin was used as loading control. Densitometry values are shown at the bottom, normalized to the control. (c) Western blot showing p27, MYC and BCL6 protein levels in Raji cells treated as above. The blots were cropped for improved clarity and the full-length blots were included in the Supplementary Information file.

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