Table 1 The comparison of biochemical parameters at the time of diagnosis of hypothyroidism in the course of Hashimoto’s thyroiditis (T0) and in euthyroidism at follow-up (T1).
Parameter [unit] | Reference range | HT baseline (T0) Median [25–75%] | HT follow-up (T1) Median [25–75%] | p-value* |
|---|---|---|---|---|
Hepcidin [ng/mL] | 0.3–47.7 | 17.4 [7.6–20.4] | 7.7 [6.2–13.0] | 0.002 |
Fe [µg/dL] | F:37–145 | 92 [77–97] | 78 [66–99] | NS |
M:59–158 | 77 [77–92] | 90 [87–97] | ||
Ferritin [ng/mL] | F:13–150 | 48 [23–72] | 48 [24–100] | NS |
M:30–400 | 179 [163–236] | 175 [170–223] | ||
TSH [µIU/mL] | 0.2–4.2 | 65.8 [33.4–100.0] | 0.9 [0.1–1.5] | <0.001 |
fT3 [pmol/L] | 3.9–6.7 | 2.6 [1.9–3.1] | 4.9 [4.6–6.1] | <0.001 |
fT4 [pmol/L] | 11.5–21.0 | 4.7 [2.6–7.9] | 20.6 [18.7–24.1] | <0.001 |
aTPO [IU/mL] | <34.0 | 508.0 [171.5–600.0] | 481.0 [173.5–600.0] | NS |
aTG [IU/mL] | 10–115 | 462.0 [183.5–820.7] | 251.0 [101.2–1002.5] | NS |
ALT [U/L] | 10.0–41.0 | 21.0 [14.7–41.0] | 20.5 [11.8–40.0] | NS |
AST [U/L] | 10.0–37.0 | 26.0 [18.2–40.2] | 22.0 [16.0–29.0] | NS |
CRP [mg/L] | <5.0 | 0.5 [0.3–2.7] | 1.5 [0.5–5.3] | NS |
Creatinine [mg/dL] | 0.5–1.2 | 1.0 [0.8–1.1] | 0.7 [0.7–0.8] | 0.011 |
GFR [mL/min/1.73 m2] | >60 | 76.2 [58.9–84.4] | 95.0 [83.3–108.0] | <0.001 |
