Figure 1
From: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy
miRNA gene promoters are preferential target sites of aberrant DNA methylation in FECD. (a) Volcano plot shows the function of disease effect (log2 (fold change), x-axis) versus the statistical significance of the result (−log 10 (p-value), y-axis) for a total number of 2,227 probes targeting miRNAs genes on the array. Each dot represents an individual probe. Vertical dotted lines represent fold changes of ±1.3, respectively. The horizontal dotted line indicates the p-value cutoff point (0.05; -log10(0.05) = 1.30103). The dots represent 216 selected differentially expressed probes with p-value < 0.05 and |fold-change| > 1.3. (b) Number of differentially methylated probes between FECD and control samples (p-value < 0.05), grouped by the probe targeting region in related miRNA genes. (c) Genome location of hypermethylated miRNA probes relative to the corresponding host genes. (d) Genomic location of hypomethylated miRNA probes relative to the corresponding host genes.
