Table 1 Top 20 most significantly differently methylated miRNAs in FECD, with 18 of them being hypermethylated and 2 being hypomethylated.
From: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy
Gene | Probe ID | Host genes | Fuchs_Coeffa | Fuchs_Pval | Fuchs_Qval |
|---|---|---|---|---|---|
miR-199B | cg13718827 | DNM1 (antisense; intronic) | 2.3595 | *** | 0.00128 |
miR-33B | cg04805065 | SREBF1 (sense; intronic) | 2.1974 | * | 0.12825 |
miR-874 | cg18251187 | KLHL3 (sense; intronic) | 2.0571 | ** | 0.00944 |
miR-1286 | cg08221669 | RTN4R (sense; intronic) | 1.7488 | ** | 0.02761 |
miR-1306 | cg20689730 | DGCR8 (sense; exonic) | 1.6852 | ** | 0.03932 |
miR-130A | cg10512089 | intergenic | 1.6548 | * | 0.09226 |
miR-320B1 | cg25023761 | intergenic | 1.5556 | ** | 0.02459 |
miR-641 | cg26620021 | AKT2 (sense; intronic) | 1.5535 | ** | 0.03169 |
miR-942 | cg19582647 | TTF2 (sense; intronic) | 1.5362 | * | 0.82808 |
miR-499 | cg11231913 | MYH7B (sense; intronic) | 1.5245 | *** | 0.00004 |
miR-30B | cg25964744 | intergenic | 1.4986 | * | 0.75198 |
miR-184 | cg23721598 | ANKRD34C-AS1(antisense; intronic) | 1.4823 | ** | 0.02005 |
miR-194-2 | cg24803202 | MIR194-2HG (sense; exonic) | 1.4674 | * | 0.42089 |
miR-25 | cg22638766 | MCM7 (sense; intronic) | 1.4593 | * | 0.13411 |
miR-662 | cg26775123 | MSLNL (antisense; exonic) | 1.4426 | * | 0.80350 |
miR-1471 | cg06046580 | intergenic | 1.3949 | * | 0.08720 |
miR-199A1 | cg18544365 | DNM2 (antisense; intronic) | 1.3434 | * | 0.26307 |
miR-320D1 | cg23483562 | intergenic | 1.2870 | * | 0.60071 |
miR-1182 | cg20821842 | FAM89A (sense; exonic) | −3.0805 | ** | 0.00667 |
miR-193A | cg08667128 | intergenic | −1.4483 | *** | 0.00030 |
