Figure 7
Effect of iPLA2γ on delivery of mitochondria to autophagosomes. WT and iPLA2γ KO GECs were co-transfected with RFP-LC3 and mito-YFP cDNAs. Cells were then incubated with or without chloroquine (CQ) for 6 h. Representative photomicrographs and the Pearson correlation coefficient (PCC) for the colocalization of RFP-LC3 and mito-YFP are presented. Bar = 25 µm. *P < 0.01 KO vs WT, **P < 0.05 KO + CQ vs WT + CQ. 23–29 cells per group in 4 experiments.
