Figure 8
Effect of iPLA2γ on delivery of mitochondria to lysosomes. WT and iPLA2γ KO GECs were co-transfected with RFP-LAMP1 and mito-YFP cDNAs. Cells were then incubated with or without chloroquine (CQ) for 6 h. Representative photomicrographs and the Pearson correlation coefficient (PCC) for the colocalization of RFP-LAMP1 and mito-YFP are presented. Bar = 25 µm. *P < 0.05 KO + CQ vs WT + CQ. 7–8 cells per group in 2 experiments.
