Table 3 LD test results for 18 pairs of syntenic loci formed when combining loci included in the SureID 23comp and GlobalFiler kits.

From: An evaluation of the SureID 23comp Human Identification Kit for kinship testing

Chr.	Syntenic Pair	LD test P-value	HapMap proxy SNP position (GRCh37)^b	Cumulative genetic map distance in cM^b	Genetic map distance in cM	RFs from Kosambi mapping function^a–c	RFs estimated based on family studies^d–f
Chr.2	TPOX	0.97764	1493487	1.6661	88.8129	0.4721^a	0.53^d
	D2S441		68239020	90.47903
Chr.2(p-q)	D2S1338	0.99164	218879435	223.4832	133.0042	0.4951^c	0.58^d
	D2S441		68239020	90.47903
Chr.2(p-q)	TPOX	0.79338	1493487	1.6661	221.8171	0.4999^c	0.51^d
	D2S1338		218879435	223.4832
Chr.3(p-q)	D3S1358	0.99193	45582627	67.1789	90.0624	0.4735^a	0.64^d
	D3S1744		147092143	157.24131
Chr.4(p-q)	FGA	0.99771	155508100	156.81293	143.8662	0.4968^c	0.51^d
	D4S2366		6484806	12.9467
Chr.5	D5S2800	0.15198	58698677	70.3208	56.3520	0.4050^b	N/A
	D5S818		123111652	126.67284
Chr.5	D5S2800	0.85646	58698677	70.3208	84.1132	0.4666^c	N/A
	CSF1PO		149455757	154.43395
Chr.5	D5S818	0.69008	123111652	126.67284	27.7611	0.2522^a	0.18^d
	CSF1PO		149455757	154.43395
Chr.6	SE33	0.99963	88986609	95.44921	23.2133	0.2168^a	0.19^d
	D6S474		112879893	118.66248
Chr.7(p-q)	D7S3048	0.98684	21266723	36.14071	64.0605	0.4284^b	0.4997^e
	D7S820		83789257	100.2012
Chr.8	D8S1132	0.23577	107330479	119.96228	16.4809	0.1591^a	0.1443^e
	D8S1179		125907927	136.44313
Chr.11	TH01	0.20421	2192166	4.48933	28.3996	0.2569^b	0.2152^e
	D11S2368		19281171	32.88891
Chr.12	vWA	0.89307	6093924	15.63031	11.9410	0.1172^a	0.1259^e
	D12S391		12450501	27.57129
Chr.13	D13S325	0.97422	43173444	44.90825	34.9225	0.3016^b	0.2533^e
	D13S317		82721723	79.83074
Chr.18	D18S51	0.04312	60949983	88.92051	2.2970	0.0229^b	0.0327^e
	D18S1364		63400151	91.21746
Chr.19(p-q)	D19S433	0.78742	30417603	51.72618	12.4538	0.1228^b	0.1101^f
	D19S253		15728103	39.27234
Chr.21	D21S11	1	20554558	14.64555	34.8192	0.3010^a	0.32^d
	D21S2055		41191871	49.46478
Chr.22	D22S1045	0.98893	37535663	46.21362	38.8178	0.3253^b	N/A
	D22GATA198B05		17651831	7.39585
Chr.15*	Penta E	—	97377441	124.05054	74.5331	0.4517^b	N/A
	D15S659		46371620	49.51748
Chr.21*	Penta D	—	45056178	59.37591	9.9111	0.0978^b	N/A
	D21S2055		41191871	49.46478

This test was performed for data generated from the 500 samples from Saudi population for the 38 loci. No significant deviation from linkage equilibrium (LE) was detected (P-value = 0.003). RFs that previously derived from HapMap data and from family studies were reviewed from literature^{4,12,21,22,24}. RFs derived from HapMap data for D2S1338-D2S441, TPOX-D2S1338, FGA-D4S2366 and D5S2800-CSF1PO pairs, were calculated based on cumulative genetic map distance provided in Phillips¹² and using Excel tool developed by Phillips et al.⁴.
^aData reviewed from Phillips et al.⁴^.
^bData reviewed from Phillips¹²^.
^cRFs were calculated based on cumulative genetic map distance provided in Phillips¹² and using an excel tool developed by Phillips et al.⁴.
^dData reviewed from Westen et al.²¹.
^eData reviewed from Liu et al.²².
^fData reviewed from Wu et al.²⁴.
*Potential syntenic pairs when combining the SureID 23comp with kits that include the Penta E and Penta D loci (LD was not tested).
N/A: No data available from family studies.

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Table 3 LD test results for 18 pairs of syntenic loci formed when combining loci included in the SureID 23comp and GlobalFiler kits.

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