Figure 5 | Scientific Reports

Figure 5

From: Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Figure 5

Biodistribution of 57Co-X-PEG2-RM26 (X = NOTA, NODAGA, DOTA and DOTAGA) in PC-3 xenografted BALB/C nu/nu mice (A) 3 h and (C) 24 h pi. Tumor-to-normal-tissue ratios (B) 3 h and (D) 24 h pi. Data were analyzed by one-way ANOVA with Bonferroni correction for multiple comparisons. Significant difference (p < 0.05) at the same time point. a. Significantly different from NOTA b. Significantly different from NODAGA c. Significantly different from DOTA d. Significantly different from DOTAGA.

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