Figure 2
From: Sirtuin 3 deficiency does not impede digit regeneration in mice
Femurs but not P3 bones of SIRT3−/− mice show homeostatic defects. μCT analysis of the uninjured P3 bone reveals (a) total bone volume, (b) cortical porosity, and (c) cortical thickness are comparable between SIRT3−/− and 129S wildtype littermates (N = 5 mice, N = 20 digits). (d,e) SIRT3−/− femurs show decreased cortical porosity compared to 129S control mice. (f) Representative μCT images of the trabecular bone of the femur of adult 129S and SIRT3−/− mice. N = 4 with representative sample shown. Scale bar represents 500 μm. Error bars represent SEM *p = 0.023.
