Table 2 Genome-wide association analysis of serum urate stratified by center.

SNP	Minor Allele	MAF	P-value	β	SE	Effect Size	Gene	Gene loc	Chr	Chr pos hg18
Arizona
rs13145758	A	0.43	1.1 × 10⁻¹⁰	−0.35	0.05	0.06	SLC2A9	Intron	4	9981997
rs9998811	G	0.44	7.4 × 10⁻¹⁰	−0.33	0.05	0.06	SLC2A9	Intron	4	9966477
rs7862063	G	0.41	4. 5 × 10⁻⁸	0.29	0.05	0.04	—	—	9	110002036
rs4481233	A	0.41	2.3 × 10⁻⁶	−0.26	0.05	0.03	SLC2A9	Intron	4	9956079
rs6688009	A	0.01	9. 1 × 10⁻⁶	1.07	0.24	0.03	PPAP2B	Intron	1	24593576
Dakotas
rs4481233	A	0.25	6. 7 × 10⁻⁸	−0.29	0.05	0.04	SLC2A9	Intron	4	9956079
rs7696092	C	0.19	1. 6 × 10⁻⁶	−0.29	0.06	0.03	SLC2A9	Intron	4	10025320
rs179409	G	0.45	3.4 × 10⁻⁶	−0.23	0.05	0.03	KCNQ1	Intron	11	2483882
rs9998811	A	0.41	4.2 × 10⁻⁶	−0.22	0.05	0.03	SLC2A9	Intron	4	9966477
rs13145758	G	0.40	5.1 × 10⁻⁶	−0.22	0.05	0.03	SLC2A9	Intron	4	9981997
rs7947391	A	0.22	5.6 × 10⁻⁶	−0.26	0.06	0.02	NPAS4	Intron	11	66186882
Oklahoma
rs4481233	A	0.30	3.3 × 10⁻⁹	−0.30	0.05	0.06	SLC2A9	Intron	4	9956079
rs9998811	A	0.46	5.8 × 10⁻⁷	−0.23	0.05	0.04	SLC2A9	Intron	4	9966477
rs4148155	G	0.20	1.1 × 10⁻⁷	0.29	0.06	0.03	ABCG2	Intron	4	89054667
rs2231142	A	0.20	1.1 × 10⁻⁶	0.29	0.06	0.03	ABCG2	Missense	4	89052323
rs1481012	G	0.20	1.1 × 10⁻⁶	0.29	0.06	0.03	ABCG2	Intron	4	89039082
rs7696092	C	0.29	2.1 × 10⁻⁶	−0.25	0.05	0.04	SLC2A9	Intron	4	10025320
rs13145758	G	0.45	2.7 × 10⁻⁶	−0.22	0.05	0.03	SLC2A9	Intron	4	9981997
rs746075	A	0.36	2.8 × 10⁻⁶	0.22	0.05	0.04	NUCB1	Intron	19	49416936

^*SNP: single nucleotide polymorphism; MAF: minor allele frequency; P-value: P-values from measured genotype analysis; β: beta coefficient of the SNP; SE: standard error; Effect Size: Proportion of the residual phenotypic variance that is explained by the minor allele of the SNP; Gene loc: Gene location; Chr pos: chromosome position in base pairs; SLC2A9: solute carrier family 2, member 9; PPAP2B: phosphatidic acid phosphatase type 2; KCNQ1: voltage gated KQT-like subfamily Q, member 1; ATP13A5: ATPase type 13A5; ABCG2: ATP-binding cassette family G, member 2; NUCB: Nucleobindin.

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