Table 5 Replication of the associations observed in SHFS.

From: Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study

Genea

SNPb

Chr: Chr.pos.hg19

Proxy SNPc

American Indian ancestry

Mexican-Mestizo ancestry

European ancestryd

Indian ancestry

East Asian ancestrye

Minor allele (frequency)

β (SE)f

P value

Minor allele (frequency)

β (SE)

P value

Minor allele (frequency)

β (SE)

P value

Minor allele (frequency)

β (SE)

P value

Minor allele (frequency)

β (SE)

P value

PLPP3

rs6688009

1: 24593576

 

A (0.01)

1.1 (0.2)

9.1 × 10−6

A (0.07)

0.08 (0.06)

0.20

T (0.17)

0.004 (0.007)

0.58

   

T (0.01)

0.04 (0.02)

0.05

SLC2A9

rs62293300

4: 9890359

 

T (0.01)

0.44 (0.2)

0.052

A (0.03)

0.17 (0.09)

0.07

         

SLC2A9

NOVEL

4: 9896970

 

C (0.05)

0.25 (0.12)

0.03

            

SLC2A9

NOVEL

4: 9897372

rs13136962

A (0.34)

0.15 (0.05)

0.001

      

G (0.44)

0.07 (0.06)

0.20

C (0.32)

−0.03 (0.004)

7.3 × 10−11

SLC2A9

NOVEL

4: 9923260

 

T (0.01)

−0.57 (0.22)

0.008

            

SLC2A9

NOVEL

4: 9930721

 

T (0.001)

−1.47 (0.8)

0.049

            

SLC2A9

NOVEL

4: 9931893

 

C (0.001)

2.2 (1.1)

0.039

            

SLC2A9

NOVEL

4: 9986995

 

C (0.26)

−0.13 (0.06)

0.031

            

SLC2A9

rs4385059

4: 9989233

rs6449213

 

−0.34 (0.04)

3.7 × 10−20

G (0.22)

−0.48 (0.04)

3.1 × 10−41

C (0.18)

0.39 (0.007)

0.000

G (0.18)

− 0.17 (0.07)

0.019

C (0.01)

0.20(0.02)

3.9 × 10−19

SLC2A9

rs28592748

4: 9998605

rs6449213

 

−0.36 (0.04)

2.7 × 10−22

A (0.24)

−0.48 (0.04)

8.6 × 10−35

C (0.18)

0.39 (0.007)

0.000

G (0.18)

− 0.17 (0.07)

0.019

T (0.01)

0.18 (0.02)

7.4 × 10−16

SLC2A9

rs7696092

4: 10025320

rs4543113

C (0.29)

−0.31 (0.05)

1 × 10−10

C (0.26)

−0.44 (0.03)

7.0 × 10−39

A (0.40)

0.17 (0.005)

3.7 × 10−202

G (0.25)

−0.13 (0.06)

0.034

C (0.01)

0.18 (0.02)

5.1 × 10−16

SLC2A9

NOVEL

4: 10026105

 

A (0.001)

2.2 (1.1)

0.037

            

SLC2A9

NOVEL

4: 10027969

 

T (0.26)

−0.32 (0.05)

5.4 × 10−10

            

SLC2A9

NOVEL

4: 10030657

 

G (0.001)

2.12 (1.0)

0.039

            

SLC2A9

NOVEL

4: 10036877

 

C (0.0007)

1.12 (0.6)

0.066

            

SLC2A9

NOVEL

4: 10039575

 

G (0.012)

0.57 (0.24)

0.02

            

-

rs7862063

9: 110002036

rs10978764

G (0.41)

0.29 (0.05)

4.5 × 10−8

A (0.18)

−0.008 (0.05)

0.86

C (0.40)

0.002 (0.006)

0.72

G (0.43)

0.015 (0.06)

0.79

C (0.35)

0.001 (0.005)

0.75

KCNQ1

11_2483882

11: 2483882

 

A (0.45)

−0.23 (0.05)

3.4 × 10−6

            

NPAS4

rs7947391

11: 66186882

 

A (0.22)

−0.26 (0.06)

5.6 × 10−6

G (0.48)

0.011 (0.04)

0.77

A (0.19)

−0.0009 (0.006)

0.89

A (0.20)

0.057 (0.07)

0.39

A (0.23)

−0.01 (0.005)

0.003

NUCB1

rs746075

19: 49416936

 

A (0.41)

0.22 (0.05)

2.8 × 10−6

   

T (0.42)

0.002 (0.008)

0.80

A (0.37)

−0.106 (0.06)

0.067

A (0.41)

−0.0003 (0.004)

0.95

  1. aPLPP3 or PPAP2B: Phospholipid phosphatase 3; SLC2A9: Solute carrier family 2 member 9; KCNQ1: Potassium voltage-gated channel subfamily Q member 1; NPAS4: Neuronal PAS domain protein 4;
  2. NUCB1: Nucleobindin 1; bSNP: Single nucleotide polymorphism (index SNP); cProxy SNP: SNP in high LD with the index SNP. Used by replication studies when the original SNP data were not available; dhttp://metabolomics.helmholtz-muenchen.de/gugc/ and http://useast.ensembl.org/Homo_sapiens/Variation/Explore?r=4:9950721; eKanai et al. 2018; Nature Genet. fβ (SE): Beta coefficient (standard error).
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