Table 1 The checkerboard method representing the effect of antimicrobials against P. aeruginosa MMA83.

From: Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones

Antimicrobials

Pseudomonas aeruginosa MMA83

MIC of each antimicrobial (mg/ml)

FIC

∑FIC

Outcome

Alone

Combination

QSI extract

20

1.25

0.0625

0.125

synergistic

Meropenem

0.512

0.032

0.0625

  

DMSO

145.45

145.45

1

3

indifferent

Meropenem

0.512

1.024

2

  

QSI extract

20

0.625

0.03125

0.047

synergistic

Gentamycin

4.096

0.064

0.0156

  

DMSO

145.45

145.45

1

2

indifferent

Gentamycin

4.096

4.096

1

  
  1. FIC – fractional inhibitory concentration, FIC = MIC combination/MIC alone.
  2. ∑FIC – sum of two FICs, ∑FIC = FIC of antibiotic + FIC of QSI extract or DMSO.