Figure 5
From: Identification of Circulating Serum Multi-MicroRNA Signatures in Human DLBCL Models
Presence of the miRNA signature for DLBCL patients in remission. (A) t-SNE plot showing the distribution of the overall response of the circulating miRNA signature (containing all 9 miRNAs) from the serum between the DLBCL in remission for <24 months (red), DLBCL patients in remission for ≥24 months (olive), DLBCL patients with the length of remission unknown (grey), DLBCL patients which at the time blood collection were categorized as remission, by follow up data indicates that patients relapsed with DLBCL (purple), and healthy subjects (blue). In addition, the DLBCL remission patients were classified as 1st remission (●) or 2nd remission (▲). (B) Receiver Operating Curves (ROCs) for the Remission (n = 52) vs. Healthy (n = 17) Samples. The area under the curve is shown in parentheses. (C) t-SNA plot determined by using the 5 most significant miRNAs (Supplemental Tables S4 and S5) for the same patient samples as in the previous plot. (D) Heatmap representing hierarchical clustering of the circulating miRNA signature. The specific subject information for age, MYC status, state of tumor, length of remission, either 1st or 2nd remission, relapse after categorized as remission during blood draw, and miRNA cancer impact is shown. For all plots the miRNA amounts were log2(x + 1) transformed.
