Figure 4
From: PGC-1β Induces Susceptibility To Acetaminophen-Driven Acute Liver Failure
Hepatic PGC-1β overexpression markedly increases lipogenic genes even under APAP challenge. Eight weeks old WT and age matched LivPGC-1β mice were intraperitoneally injected with either APAP (300 mg/Kg body weight) or equal volume of saline as vehicle control. Liver tissues were harvested 3 hours later. Analysis of serum triglycerides (A) and cholesterol (B) collected from mice. (C) Relative expression of genes involved in fatty acids synthesis and excretion. Relative Gene Expression was evaluated by Real Time qPCR in liver specimens from different groups, using TBP as housekeeping gene. Comparison of different groups (n = 6 mice/group) was performed using Two-way ANOVA followed by Bonferroni post-test. Data from groups sharing the same lowercase letters were not significantly different, whereas data from groups with different case letters were significantly different (p < 0.01).
