Table 1 Detection of CD34-positve monocytes and characteristics of patients and donors.

From: Increased CD83 expression of CD34-positive monocytes in donors during peripheral blood stem cell mobilization in humans

Donor background

 

CD34+ monocytes

P-value

negative (n = 36)

positive (n = 37)

Donor Age

Median (range)

41 (17–64)

39 (14–63)

0.78

Donor Gender

Female

26

17

0.03

Male

10

20

Body Weight

Median (range)

58.0 kg (40.8–88.3)

62.5 kg (45.4–96.0)

0.51

Dose of CD34+cells collected at the first day

Median (range)

1.64 × 108 cells (0.27–7.78)

2.07 × 108 cells (0.38–11.9)

0.09

Total dose of CD34+cells during their mobilization

Median (range)

2.64 × 108 cells (1.27–7.78)

2.20 × 108 cells (1.40–11.9)

0.45

% of peripheral monocytes at harvest

Median (range)

4.2% (1.4–9%)

4.80% (2.2–13.2%)

0.08

Patient background

Patient Age

Median (age)

44 (20–66)

41 (19–66)

0.96

Patient Gender

Female

13

19

0.24

Male

23

18

Disease

ALL

7

9

0.47

AML

13

19

ML

6

3

MPN MDS

5

2

others

5

4

Disease risk

standard

22

20

0.64

high

14

17

Prior transplant

no

32

28

0.22

yes

4

9

CMV sero-positivity

negative

3

5

0.71

positive

33

32

HLA-match

match

16

21

0.35

mismatch

20

16

GVHD prophylaxis

CsA-based

35

35

1

Tac-based

1

2

In vivo T cell depletion

no

24

23

0.81

Yes

12

14

Conditioning

MAC

27

27

1

RIC

9

10

  1. AML, acute myelogeneous leukemia; ALL, acute lymphoblastic leukemia; ML, malignant lymphoma; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; CMV, cytomegalovirus; GVHD, graft-versus-host disease; CsA, cyclosporine; TAC, tacrolimus; MAC, myeloablative conditioning; RIC, reduced-intensity conditioining.