Table 1 Detection of CD34-positve monocytes and characteristics of patients and donors.
Donor background | CD34+ monocytes | P-value | ||
|---|---|---|---|---|
negative (n = 36) | positive (n = 37) | |||
Donor Age | Median (range) | 41 (17–64) | 39 (14–63) | 0.78 |
Donor Gender | Female | 26 | 17 | 0.03 |
Male | 10 | 20 | ||
Body Weight | Median (range) | 58.0 kg (40.8–88.3) | 62.5 kg (45.4–96.0) | 0.51 |
Dose of CD34+cells collected at the first day | Median (range) | 1.64 × 108 cells (0.27–7.78) | 2.07 × 108 cells (0.38–11.9) | 0.09 |
Total dose of CD34+cells during their mobilization | Median (range) | 2.64 × 108 cells (1.27–7.78) | 2.20 × 108 cells (1.40–11.9) | 0.45 |
% of peripheral monocytes at harvest | Median (range) | 4.2% (1.4–9%) | 4.80% (2.2–13.2%) | 0.08 |
Patient background | ||||
Patient Age | Median (age) | 44 (20–66) | 41 (19–66) | 0.96 |
Patient Gender | Female | 13 | 19 | 0.24 |
Male | 23 | 18 | ||
Disease | ALL | 7 | 9 | 0.47 |
AML | 13 | 19 | ||
ML | 6 | 3 | ||
MPN MDS | 5 | 2 | ||
others | 5 | 4 | ||
Disease risk | standard | 22 | 20 | 0.64 |
high | 14 | 17 | ||
Prior transplant | no | 32 | 28 | 0.22 |
yes | 4 | 9 | ||
CMV sero-positivity | negative | 3 | 5 | 0.71 |
positive | 33 | 32 | ||
HLA-match | match | 16 | 21 | 0.35 |
mismatch | 20 | 16 | ||
GVHD prophylaxis | CsA-based | 35 | 35 | 1 |
Tac-based | 1 | 2 | ||
In vivo T cell depletion | no | 24 | 23 | 0.81 |
Yes | 12 | 14 | ||
Conditioning | MAC | 27 | 27 | 1 |
RIC | 9 | 10 | ||