Table 1 Baseline characteristics of derivation and validation cohorts.

From: Artificial liver support system therapy in acute-on-chronic hepatitis B liver failure: Classification and regression tree analysis

Variable

Derivation Cohort (n = 365)

Validation Cohort (n = 124)

P-value

Clinical parameters

Age (years)

46.52 ± 11.38

45.31 ± 11.97

0.314

Male Gender (%)

325 (89.04%)

99 (79.84%)

0.009

HTN (%)

43 (11.78%)

17 (13.71%)

0.572

DM (%)

28 (7.67%)

16 (12.90%)

0.101

Liver Cirrhosis (%)

157 (43.01%)

77 (62.10%)

<0.001

Ascites (%)

166 (45.48%)

68 (54.84%)

0.071

Hepatic Encephalopathy (%)

47 (12.88%)

16 (12.90%)

0.996

Hepatic Encephalopathy I-II (%)

27 (7.40%)

9 (7.26%)

 

Hepatic Encephalopathy III-IV (%)

20 (5.48%)

7 (5.65%)

 

Infection (%)

59 (16.16%)

29 (23.39%)

0.070

Gastrointestinal hemorrhage (%)

10 (2.74%)

8 (6.45%)

0.580

28 days-Mortality

140 (38.36%)

51 (41.13%)

0.585

Laboratory parameters

ALT (U/L)

182.00 (91.50, 371.50)

155.5 (59.25, 445.75)

0.376

AST (U/L)

138.00 (91.00, 252.00)

143.50 (65.25, 404.50)

0.782

TBil (μmol/L)

424.87 ± 123.14

402.11 ± 132.01

0.082

ALB (g/L)

32.19 ± 6.40

33.75 ± 4.48

0.012

GGT (U/L)

70.00 (50.50, 92.50)

70.00 (43.50, 119.00)

0.706

Glucose (mmol/L)

3.96 (3.27, 4.72)

6.05 (4.27, 8.70)

<0.001

INR

2.11 (1.76, 2.78)

2.28 (1.80, 3.25)

0.054

PT (s)

23.4 (19.8, 30.7)

23.35 (20.03, 35.25)

0.209

Fibrinogen (g/L)

1.21 (0.96, 1.55)

1.29 (0.96, 1.71)

0.294

D-dimer (μg/L)

2279.00 (1120.00, 3690.00)

1318.00 (562.00, 3004.50)

<0.001

ALP (U/L)

130.00 (108.50, 161.00)

118.50 (95.00, 153.75)

0.006

WBC (109/L)

8.04 ± 4.13

9.10 ± 5.40

0.023

Hb (g/L)

126.04 ± 19.73

115.24 ± 28.43

<0.001

Plt (10^9/L)

108.18 ± 48.80

95.73 ± 53.82

0.017

Serum Sodium (mmol/L)

136.79 ± 4.53

137.29 ± 9.09

0.428

Creatinine (μmol/L)

67.00 (58.50, 80.00)

63.50 (49.00, 95.00)

0.071

GFR (ml/min)

106.83 (92.79, 116.36)

111.58 (100.92, 116.09)

0.090

BUN (mmol/L)

4.30 (3.30, 5.80)

5.00 (3.40, 8.48)

0.003

NH3 (μmol/L)

67.00 (50.00, 91.50)

80.70 (51.00, 118.00)

0.002

HBV-DNA (log10, IU/ml)

5.04 ± 2.23

4.61 ± 1.81

0.055

Scoring system

MELD score

25.40 ± 5.55

26.17 ± 7.54

0.297

iMELD score

43.60 ± 7.59

43.66 ± 10.69

0.953

CLIF-C ACLF score

41.17 ± 7.00

41.89 ± 7.39

0.327

COSSH-ACLF score

6.34 (5.83, 6.96)

6.59 (5.91, 7.52)

0.056

  1. Abbreviations: HTN, hypertension; DM, diabetes mellitus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBil, total bilirubin; ALB, albumin; GGT, gamma-glutamyl transpeptidase; INR, internationalized normal ration; PT, prothrombin time; ALP, alkaline phosphatase; WBC, white blood cell; Hb, hemoglobin; Plt, platelet; GFR, glomerular filtration rate; BUN, urea nitrogen; HBV-DNA, hepatitis B virus- deoxyribonucleic acid; MELD, Model for End-stage Liver Disease; iMELD, integrated model for end-stage liver disease; CLIF-C ACLF, Chronic Liver Failure Consortium acute-on-chronic liver failure; COSSH-ACLF, Chinese group on the Study of Severe Hepatitis B-acute-on-chronic liver failure.
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