Figure 3 | Scientific Reports

Figure 3

From: Metabolic Effects of JAK1/2 Inhibition in Patients with Myeloproliferative Neoplasms

Figure 3The alternative text for this image may have been generated using AI.

Changes in adipose tissue mass and signaling after ruxolitinib treatment. Abdominal CT images at lumbar vertebra L3 level before (A) and after (B) treatment with ruxolitinib in a patient with 4.1 kg (6.5%) body weight gain. Red coloration indicates adipose tissue. (C) Western blot analysis of STAT5 phosphorylation in gonadal adipose tissue from C57BL/6J mice fed high fat diet (HFD), or regular chow (RC), and acutely treated with ruxolitinib, rhGH or vehicle, as indicated.

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