Figure 1
From: Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness
Polycystin-1 interactome study. (a) Proteomic workflow of the SILAC experiments for the identification of polycystin-1 interactome. (b) Example of HA IP showing PC-1. Full-length blot is presented in Supplementary Fig. 1. (c) All identified proteins were plotted according to their signal intensities and their heavy versus light ratio on logarithmic scales. (d) Histogram of the Log2 ratio H/L of the putative Pkd1 interactors in SILAC1 and SILAC2. (e) Functional protein association networks of the putative polycystin-1 interactors as reported in STRING database. In the network, links between proteins represent interaction data supporting the network. Additionally, enriched KEGG Biological Pathways (p < 0.05) are reported and the protein associated are color code circled.
