Table 5 Overlapping top SNVs from our biomarker GWAS with WGS data and top SNVs from the eQTL analyses by Westra et al.51.
Gene name | Biomarker | Top SNV (biomarker GWAS) | Annotation | Top SNV (eQTL) | LD | P (biomarker GWAS) | P (eQTL) |
|---|---|---|---|---|---|---|---|
CD40 | CD40 (INF) | rs1569723 | intergenic (NCOA5;CD40) | rs1569723 | 1 | 5.24 × 10−43 | 1.06 × 10−28 |
CD40 | CD40 (ONC_CVD) | rs4239702 | intronic (CD40) | rs4239702 | 1 | 1.01 × 10−49 | 1.26 × 10−34 |
CXCL5 | CXCL5 (INF) | rs352045 (cis)* | upstream (CXCL5) | rs352045 | 1 | 6.09 × 10−27 | 4.25 × 10−111 |
CXCL5 | CXCL5 (ONC_CVD) | rs425535 (cis)* | exonic (CXCL5) | rs425535 | 1 | 1.09 × 10−34 | 4.50 × 10−111 |
IL15RA | IL-15RA | rs3136630 | intronic (IL15RA) | rs3136630 | 1 | 2.64 × 10−19 | 5.21 × 10−6 |
CXCL5 | CXCL5 (INF) | rs10740118 (trans)** | intronic (JMJD1C) | rs10761779 | 0.856 | 2.93 × 10−13 | 1.82 × 10−7 |
CXCL5 | CXCL5 (ONC_CVD) | rs7088799 (trans)** | intronic (JMJD1C) | rs10761779 | 0.856 | 7.36 × 10−16 | 1.82 × 10−7 |
IL18R1 | IL-18R1 | rs12999517† | intronic (IL1RL1) | rs12999517 | 1 | 4.89 × 10−19 | 1.13 × 10−39 |
TNFSF14 | TNFSF14 | rs2291668† | synonymous (TNFSF14) | rs1077667 | 0.899 | 4.71 × 10−07 | 4.36 × 10−47 |
CCL23 | CCL23 | rs854671‡ | intergenic (CCL23;CCL18) | rs854671 | 1 | 1.48 × 10−08 | 3.21 × 10−27 |
