Table 3 Pharmacokinetic parameters obtained in the plasma of mice treated with ifosfamide (IF) alone, and with a previous administration of naringin or grapefruit juice (GFJ).

From: Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin

Measured Parameter

IF only (300 mg/kg)

Naringin + IF (250 mg/kg + 300 mg/kg)

GFJ + IF (20.8 µL/g + 300 mg/kg)

Cmax (μg/mL)

58.08 ± 5.01

64.12 ± 4.37a♣

71.35 ± 3.57a♣

Tmax (min)

10.83 ± 1.28

5 ± 0.68a♦

8.75 ± 2.05

\(AU{C}_{0-}\)∞ (μg*min/mL)

2110.36 ± 114.98

2245.40 ± 211.9

2052.03 ± 102.33

t1/2 (min)

23.55 ± 1.86

26.77 ± 3.77

16.54 ± 1.43a♦

  1. Naringin and GFJ were administered 1 h before IF. n = 3.
  2. Values represent mean ± SEM, this were obtained with the WinNonlin 4.0 software. aStatistically significant difference with respect to the value obtained from treated group with IF (300 mg/kg).
  3. ♣One way ANOVA, pos hoc Student-Newman-Keuls (p ≤ 0.05).
  4. ♦Kruskal-Wallis, pos hoc Student-Newman-Keuls (p ≤ 0.05).
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