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Figure 1

From: Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function

Figure 1

AR-BP sidedness impacts endothelial proliferation but not adhesion. (A) Adhesion of hAEC to AR-BP scaffolds (fibrous vs serous side). Each point represents mean of AlamarBlue intensity 6 h after seeding ± SD, n = 7 per seeding density per side (****p < 0.0001, *p < 0.05, for serous side). The presence of a basement membrane has no effect on hAEC adhesion in AR-BP scaffolds. (B) Proliferation of hAEC following seeding on AR-BP scaffolds. hAEC proliferation at 6 h post-seeding is significantly higher following seeding on the serous side versus the fibrous side. (C–F) hAEC proliferation following seeding at a density of (D) 71 cell/mm2; (C) 142 cell/mm2; (E) 284 cell/mm2; and (F) 568 cell/mm2, on the fibrous vs serous side of AR-BP scaffolds. Cell proliferation was significantly greater on the serous side than on the fibrous side at lower seeding densities.

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