Figure 6 | Scientific Reports

Figure 6

From: Upregulation of caveolin-1 and its colocalization with cytokine receptors contributes to beta cell apoptosis

Figure 6The alternative text for this image may have been generated using AI.

Schematic of the mechanism by which involvement of cav-1 and caveolae in CM-induced beta cell apoptosis in pancreatic beta-cells. Cytokine mixture treatment into beta cells inhibited insulin secretion and induced apoptosis. Cytokine mixture treatment increased caveolae structure as well as cav-1 expression and cytokine receptors (TNFR1 and IL1-R1) were recruited into caveolae. Therefore, activation of NF-kB signaling pathway increased the expression level of inflammatory response genes, which leads to beta cell apoptosis.

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