Table 1 Pharmacokinetic parameters after the administration of 10% FF injection and FF-HP-β-CD solution (n = 6).

From: Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs

Pharmacokinetic parameters

10% FF injection

FF-HP-β-CD solution

t1/2α (h)

0.77 ± 0.08

0.29 ± 0.07*

t1/2β (h)

0.98 ± 0.19

1.92 ± 0.15*

Ka (1/h)

5.05 ± 0.25

3.66 ± 0.41*

V1/F (L/kg)

1.11 ± 0.21

0.72 ± 0.17**

CL/F (L/h/kg)

0.87 ± 0.14

0.81 ± 0.08

AUC(0–6 h) (mg/L*h)

21.64 ± 2.38

22.13 ± 2.88

AUC(0–∞) (mg/L*h)

23.65 ± 2.39

24.54 ± 2.84

K10 (1/h)

0.54 ± 0.023

1.16 ± 0.23**

K12 (1/h)

0.32 ± 0.10

0.96 ± 0.35**

K21 (1/h)

0.56 ± 0.02

1.04 ± 0.21*

Cmax (mg/L)

11.56 ± 1.54

15.90 ± 3.15*

Tmax (h)

0.58 ± 0.13

0.44 ± 0.09*

  1. *P < 0.05, **P < 0.01, compared with 10% FF injection.
Back to article page