Table 3 Using various amounts of NH2OH⋅HCl for 211At isolation and its influence on the B10-conjugated MAb labeling yield.

From: Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system

NH2OH·HCl

(% Vmin)

% Captured by

Te column

% Activity in

HCl wash (20 mL)

% Activity in

H2O wash (20 mL)

% 211At eluted in the 1st

1 mL NaOH

(decay-corrected)

% B10-conjugated

MAb labeling yield

≥100

>99.9

<0.1

<0.1

78.9–87.7

10.4–94.7

95

>99.9

<0.1

<0.1

86.6

17.0

83

>99.9

<0.1

<0.1

83.7

26.0

80

98.7

<0.1

<0.1

80.5

23.4

68

>99.9

0.13

<0.1

78.1

29.8

52

99.5

0.20

<0.1

79.8

82.5

46

98.9

0.30

<0.1

70.2

72.9

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