Figure 5

Tenofovir disoproxil fumarate reduces IL-1β and TNFα mRNA levels in gp120-tg brains. Total RNA was isolated from frontal cortex and analyzed by rt2PCR for IL-1β and TNFα mRNA levels. (a,b) Fold-change of IL-1β and TNFα mRNA compared to wt mice. Analyzed with two-way ANOVA test (wt, n = 3; wt + TDF, n = 3; gp120-tg, n = 3; gp120-tg, n = 3).