Figure 3 | Scientific Reports

Figure 3

From: Late recurrence of breast cancer is associated with pro-cancerous immune microenvironment in the primary tumor

Figure 3

Tumor immune microenvironment differs by timings of breast cancer recurrence in TCGA BC cohort. Box plots of the relationship between each timeframe of cancer recurrence and immune cell fractions (left to right; Leukocyte Fraction, and Lymphocyte Infiltration, and Macrophage Regulation); (A) and TCR repertoire (left to right; Shannon, Richness, and Evenness). (B,C) Pie chart of “Immune Subtypes” in each cancer recurrence timeframe. Primary BCs with cancer recurrence data was analyzed and categorized as follows: recurrence ≤2 years (Early), recurrence between 2–5 years (Mid), recurrence >5 years (Late), and no recurrence >5 years (Survivors). ***Means P < 0.001, **means P < 0.01 and *means P < 0.05. Abbreviations: TCGA, The Cancer Genome Atlas; BC, breast cancer; TCR, T cell receptor; K-W, Kruskal-Wallis; NS, not significant.

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